Ubiquitin is a small protein at the heart of many cellular processes, and several different protein domains are known to recognize and bind ubiquitin. A common motif for interaction with ubiquitin is the Ubiquitin Interacting Motif (UIM), characterized by a conserved sequence signature and often found in multi-domain proteins. Multi-domain proteins with intrinsically disordered regions mediate interactions with multiple partners, orchestrating diverse pathways. Short linear motifs for binding are often embedded in these disordered regions and play crucial roles in modulating protein function. In this work, we investigated the structural propensities of UIMs using molecular dynamics simulations and NMR chemical shifts. Despite the structural portrait depicted by X-crystallography of stable helical structures, we show that UIMs feature for both helical and intrinsically disordered motifs. Our results shed light on a new class of disordered UIMs. This group is here exemplified by the C-terminal domain of one isoform of ataxin-3 and a group of USP-containing proteins. Intriguingly, UIMs not only bind ubiquitin. They can be a recruitment point for other integrators, such as parkin and heat shock protein Hsc70-4. Disordered UIMs can provide versatility and new functions to the client proteins, opening new venues for research on their interactive.

Journal of Blood Disorders & Transfusion (ISSN: 2155-9864// NLM I'D: 101630198) is a peer reviewed and open access journal aimed to publish most interesting and complete reliable source of information on current development and advanced research findings in the mode of original articles, review articles, case reports, short communications, etc. in all areas of the field and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide.

Journal of Blood Disorders & Transfusion is an scholarly journal that focuses on all aspects of molecular genetics, pathophysiology and epidemiology as well as prevention, diagnosis, and management of blood disorders with current state of research in the field of transfusion medicine, hematology, hemato-oncology, pediatric hematology, laboratory hematology, neuropathy, blood donors, thalassemia, bone marrow transplantation, anti-HBc, haemodilution, hemodialysis, blood stem cell, blood disorders, Rh factor, blood cancer, platelet disorders, hemolytic anemia etc.

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Thank you, and Regards,
John Robert
Journal of Blood Disorders & Transfusion
ISSN: 2155-9864| NLM ID: 101630198