WAILEA, Hawaii — Perfluorocarbon liquid represents “a big advance” in the surgical approach to subretinal fluid removal when performing vitrectomy for primary retinal detachment repair, Carl D. Regillo, MD, told colleagues at Retina 2021. “It’s very well tolerated, very useful, for many of our cases, even in primary RDs under certain circumstances,” he said. Regillo uses perfluorocarbon fluid in about one-third of his cases and uses posterior drainage retinotomy and direct aspiration through a pre-existing peripheral break in other cases “The types of cases I like to use perfluorocarbon tend to be bigger, bullous, more extensive retinal detachments, and certainly the complicated ones like giant tear and [proliferative vitreoretinopathy],” he said. For primary RDs, ones that require more extensive work in the periphery, use of perfluorocarbon liquid provides “excellent” visualization of laser treatment to the retinal breaks and “excellent displacement of subretinal fluid, especially with the technique of anteriorizing the peripheral retinal breaks. That is an important aspect of getting rid of subretinal fluid,” he said. In particular with the use of perfluorocarbon liquid, when the retinal break is in a typical peripheral location, Regillo extends the break anteriorly. “I wouldn’t want to do that in a posterior break, but for breaks in the usual peripheral location, I’ll extend that break all the way to the ora. That will help maximize drainage of subretinal fluid,” he said. With any technique, some trapped posterior subretinal fluid is expected, but if the subretinal fluid is not in the macula, then face-down positioning postoperatively is not necessary in most cases, he said. Journal of Clinical and Experimental Ophthalmology is now accepting submissions on this topic. A standard EDITORIAL TRACKING SYSTEM is utilized for manuscript submission, review, editorial processing and tracking which can be securely accessed by the authors, reviewers and editors for monitoring and tracking the article processing. Manuscripts can be uploaded online at Editorial Tracking System (https://www.longdom.org/clinical-experimental-ophthalmology.html) or forwarded to the Editorial Office at manuscripts@longdom.org Regards, Lina Gilbert Managing Editor Pancreatic disorders and Therapy